Ethanol → HCID 21540472, compound

Participants

Reaction Steps

A mixture of 5 g of 2chloro-4-(1-adamantylamino)quinazoline, 5 ml of morpholine, and 10 ml of ethanol was refluxed for 16 hours. The reaction mixture was suspended in 100 ml of 6 N hydrochloric acid. The precipitate which resulted was collected by filtration and recrystallized twice from 95 percent ethanol, giving 3.5 g of 2-morpholino-4-(1-adamantylamino)quinazoline hydrochloride; m.p. 319°-321°. The following analytical data were obtained:

Provenance & Evidence