Ethanol → HCID 21540472, compound

HRID 1076363Notes

Reaction equation

HRID 1076363 reaction equation
[Cl:1][C:2]1[N:11]=[C:10]([NH:12][C:13]23[CH2:22][CH:17]4[CH2:18][CH:19]([CH2:21][CH:15]([CH2:16]4)[CH2:14]2)[CH2:20]3)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1.C(O)C>Cl>[ClH:1].[O:26]1[CH2:27][CH2:28][N:23]([C:2]2[N:11]=[C:10]([NH:12][C:13]34[CH2:14][CH:15]5[CH2:16][CH:17]([CH2:18][CH:19]([CH2:21]5)[CH2:20]3)[CH2:22]4)[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[N:3]=2)[CH2:24][CH2:25]1

Participants

5

Reactant 3

HCID 702EthanolHCID 8083MorpholineHCID 3735838HCID 3735838, compound

Product 1

HCID 21540472HCID 21540472, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 5 g of 2chloro-4-(1-adamantylamino)quinazoline, 5 ml of morpholine, and 10 ml of ethanol was refluxed for 16 hours. The reaction mixture was suspended in 100 ml of 6 N hydrochloric acid. The precipitate which resulted was collected by filtration and recrystallized twice from 95 percent ethanol, giving 3.5 g of 2-morpholino-4-(1-adamantylamino)quinazoline hydrochloride; m.p. 319°-321°. The following analytical data were obtained:

Workup

  1. temperaturewas refluxed for 16 hours
  2. customThe precipitate which resulted
  3. filtrationwas collected by filtration
  4. customrecrystallized twice from 95 percent ethanol

Sources & evidence

ORD record
ord-90ad2970f6d04682aa7153cd9abeaaeb
Source dataset
uspto-grants-1976_05
Patent number
US03956495

Reaction notes

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