Dimethylamine → HCID 21486904, compound

HRID 1076372Notes

Reaction equation

HRID 1076372 reaction equation
[CH3:1][O:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:4](OC)=[O:5].[CH3:14][NH:15][CH3:16]>C(O)C>[CH3:1][O:2][CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:4]([N:15]([CH3:16])[CH3:14])=[O:5]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 21486910Methyl 2-methoxy-2-(2-pyridyl)acetate

Product 1

HCID 21486904HCID 21486904, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 18.1 g. of methyl 2-methoxy-2-(2-pyridyl)acetate and 10 g. of dimethylamine in ethanol is stirred at room temperature for 26 hours. The mixture is concentrated, dissolved in chloroform and extracted with brine. The organic phase is dried over magnesium sulfate and filtered and the solvent is removed under reduced pressure to give 2-methoxy-N,N-dimethyl-2-(2-pyridyl)acetamide.

Workup

  1. additionA mixture of 18.1 g
  2. concentrationThe mixture is concentrated
  3. dissolutiondissolved in chloroform
  4. extractionextracted with brine
  5. dry with materialThe organic phase is dried over magnesium sulfate
  6. filtrationfiltered
  7. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-41df02ac05e54de2b054dd8c3f855d99
Source dataset
uspto-grants-1976_05
Patent number
US03956494

Reaction notes

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