Formaldehyde → HCID 53996258, compound

HRID 1076384Notes

Reaction equation

HRID 1076384 reaction equation
[CH3:1][N:2]([CH3:14])[CH:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)[C:4]([NH:6][CH3:7])=[S:5].[NH:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.[CH2:21]=O>CO>[CH3:14][N:2]([CH3:1])[C:3]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1)([CH2:21][N:15]1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1)[C:4]([NH:6][CH3:7])=[S:5]

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 8083MorpholineHCID 15581954HCID 15581954, compound

Product 1

HCID 53996258HCID 53996258, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 19.5 g. of 2-dimethylamino-N-methyl-2-(2-pyridyl)thioacetamide in 200 ml. of methanol, 13 g. of morpholine and 4.5 g. of formaldehyde is heated at reflux for 48 hours. The mixture is concentrated in vacuo and the residue is recrystallized from isopropyl ether to give 2-dimethylamino-N-methyl-3-morpholino-2-(2-pyridyl)thiopropanamide.

Workup

  1. additionA mixture of 19.5 g
  2. temperatureat reflux for 48 hours
  3. concentrationThe mixture is concentrated in vacuo
  4. customthe residue is recrystallized from isopropyl ether

Sources & evidence

ORD record
ord-85eb61bf96e8413f892992970db0eeb9
Source dataset
uspto-grants-1976_05
Patent number
US03956494

Reaction notes

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