Ethylamine → 3-(Ethylamino-methylene)-7-chloro-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
Reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:11][C:10](=[O:12])[C:9](=[CH:13][N:14]([CH3:16])C)[N:8]=[C:7]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[Cl:23])[C:6]=2[CH:24]=1.[CH2:25](N)C>C(Cl)(Cl)Cl>[CH2:16]([NH:14][CH:13]=[C:9]1[N:8]=[C:7]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[Cl:23])[C:6]2[CH:24]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=2[NH:11][C:10]1=[O:12])[CH3:25]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture consisting of 5 gm of 7-chloro-5-(2'-chloro-phenyl)-1,3-dihydro-3-(dimethylamino-methylene)-2H-1,4-benzodiazepin-2-one and 75 ml of ethylamine was heated for 20 minutes at 100°C in closed tube. Thereafter, the reaction mixture was quickly cooled, diluted with chloroform and evaporated to dryness in vacuo. The yellow, solid residue was recrystallized from absolute ethanol, yielding the compound of the formula ##SPC7##
Workup
- temperatureThereafter, the reaction mixture was quickly cooled
- customevaporated to dryness in vacuo
- customThe yellow, solid residue was recrystallized from absolute ethanol
- customyielding the compound of the formula
Sources & evidence
- ORD record
- ord-0151e614070147e0ae594f3434069cc9
- Source dataset
- uspto-grants-1976_05
- Patent number
- US03956492
Reaction notes
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