Ethylamine → 3-(Ethylamino-methylene)-7-chloro-5-(2'-chloro-phenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Participants

Reaction Conditions

Reaction Steps

A mixture consisting of 5 gm of 7-chloro-5-(2'-chloro-phenyl)-1,3-dihydro-3-(dimethylamino-methylene)-2H-1,4-benzodiazepin-2-one and 75 ml of ethylamine was heated for 20 minutes at 100°C in closed tube. Thereafter, the reaction mixture was quickly cooled, diluted with chloroform and evaporated to dryness in vacuo. The yellow, solid residue was recrystallized from absolute ethanol, yielding the compound of the formula ##SPC7##

Provenance & Evidence