Z-Thr(tbu)-ome → (2S,3R)-Methyl 2-amino-3-(tert-butoxy)butanoate

Participants

Reaction Steps

12.92 g (40mmols) of Z-Thr(tBu)-OMe are hydrogenated in 200 ml of glacial acetic acid and 3 g of Pd-charcoal (10%) at room temperature. The hydrogen uptake is finished after 1 hour. The solution is freed of the catalyst by filtration and is evaporated in a waterpump vacuum at 35°C. After drying in a high vacuum at 35°C 7.3 g of an oil result, which according to a thin layer chromatogram is a single substance and is directly further used.

Provenance & Evidence