HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 91978571, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-valyl-L-leucine methyl ester | HCID 12814326 | — |
| Catalyst | Palladiumcarbon | HCID 14818447 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 91978571 | HCID 91978571 | — |
Reaction Steps
5.66 g (15 mmols) of Z-Val-Leu-OMe are hydrogenated in 75 ml of methanol in the presence of 15 mmols of hydrochloric acid and 850 mg of Pd-charcoal (10%) at room temperature. The hydroen uptake has finished after 3 hours. The catalyst is filtered off and the solution is concentrated to about 15 ml. On addition of ether, the product crystallises out. Melting point 136° - 139°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03956260 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-6e0989a4ffa348d69b6c815e756140ae |
| Source note | uspto-grants-1976_05 |