HRID1076414

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1

HCID7021351

未命名化合物

结构：CC(C)(C)OC(=O)NNC(=O)[C@@H](N)Cc1ccccc1

HCID131710204

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1

HCID131710203

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1.4 g of H-Phe-NHNH-BOC, 1.94 g of Z-Asn-ONP and 3 ml of dimethylformamide are stirred at room temperature until the mixture solidifies. After allowing to stand overnight, the material is triturated with ether, and the dipeptide derivative is filtered off and washed with ether until free of nitrophenol. The product begins to melt at 211°C with decomposition. Rf = 0.55 in chloroform-methanol (8:2) on silica gel.

WORKUP

后处理

customthe material is triturated with ether
filtrationthe dipeptide derivative is filtered off
washwashed with ether until free of nitrophenol
customto melt at 211°C with decomposition

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-c3dfecaaed754326aa086c6b12ea780a
来源数据集: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03956260
来源说明: uspto-grants-1976_05

反应 SMILES

[NH2:1][C@H:2]([C:10]([NH:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH:21]1[CH:26]=[CH:25][C:24]([CH2:27][O:28][C:29]([NH:31][C@H:32]([C:37](OC2C=CC([N+]([O-])=O)=CC=2)=[O:38])[CH2:33][C:34]([NH2:36])=[O:35])=[O:30])=[CH:23][CH:22]=1>CN(C)C=O>[NH:31]([C:29]([O:28][CH2:27][C:24]1[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=1)=[O:30])[C@H:32]([C:37]([NH:1][C@H:2]([C:10]([NH:12][NH:13][C:14]([O:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:15])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=[O:38])[CH2:33][C:34](=[O:35])[NH2:36]