HRID1076416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)Oc1ccc([N+](=O)[O-])cc1

HCID7021351

未命名化合物

结构：CC(C)(C)OC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(N)=O

HCID131710205

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)NNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1

HCID131710206

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

PROCEDURE

实验过程

20.93 g of H-Asn-Phe-NH-NH-BOC are dissolved in 45 ml of dimethylformamide with warming, mixed with 22.7 g of Z-Asn-ONP at room temperature, and stirred until the mixture solidifies. After standing overnight, the solid mass is dissolved in 160 ml of dimethylformamide with warming, precipitated by adding dropwise to 1 liter of ether, and the product is filtered off and washed with acetone until free of nitrophenol. Rf = 0.24 in chloroform-methanol (8:2).

WORKUP

后处理

temperaturewith warming
temperaturewith warming
customprecipitated
additionby adding dropwise to 1 liter of ether
filtrationthe product is filtered off
washwashed with acetone until free of nitrophenol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-97ea28c9299340bba3f8b7fc062110ec
来源数据集: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03956260
来源说明: uspto-grants-1976_05

反应 SMILES

[NH2:1][C@H:2]([C:7]([NH:9][C@H:10]([C:18]([NH:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[O:19])[CH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5].[CH:29]1[CH:34]=[CH:33][C:32]([CH2:35][O:36][C:37]([NH:39][C@H:40]([C:45](OC2C=CC([N+]([O-])=O)=CC=2)=[O:46])[CH2:41][C:42]([NH2:44])=[O:43])=[O:38])=[CH:31][CH:30]=1>CN(C)C=O>[NH:39]([C:37]([O:36][CH2:35][C:32]1[CH:33]=[CH:34][CH:29]=[CH:30][CH:31]=1)=[O:38])[C@H:40]([C:45]([NH:1][C@H:2]([C:7]([NH:9][C@H:10]([C:18]([NH:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[O:19])[CH2:11][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:8])[CH2:3][C:4](=[O:6])[NH2:5])=[O:46])[CH2:41][C:42](=[O:43])[NH2:44]