反应详情

6.3 g of Z-Arg-Phe-Ser(tBu)-Gly-OCH3 hydrobromide (8.5 mmols) are dissolved in 350 ml of methanol and 2.9 ml of hydrogen chloride in dioxane (3.09 N, 8.9 mmols) are added. The mixture is hydrogenated in the presence of 1.2 g of 10 % strength palladium-charcoal at room temperature and atmospheric pressure. After completion of the hydrogen uptake the solution is filtered and evaporated and the resulting residue is dissolved in 30 ml of methanol and the solution stirred into 700 ml of ether. Thereby a yellowish paste is produced which is again dissolved and precipitated in the same manner.

1. filtrationAfter completion of the hydrogen uptake the solution is filtered
2. customevaporated
3. dissolutionthe resulting residue is dissolved in 30 ml of methanol
4. customThereby a yellowish paste is produced which
5. dissolutionis again dissolved
6. customprecipitated in the same manner