HCID 131710229, compound → HCID 131710228, compound

HRID 1076431Notes

Reaction equation

HRID 1076431 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][CH2:17][C:18]([N:20]1[CH2:62][CH2:61][CH2:60][C@H:21]1[C:22]([NH:24][C@H:25]([C:35]([NH:37][C@H:38]([C:46]([N:48]1[CH2:59][CH2:58][CH2:57][C@H:49]1[C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])=[O:47])[C@@H:39]([CH3:45])[O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:36])[CH2:26][CH2:27][C:28](=[O:34])[O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:23])=[O:19])=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:4]>CO.[C].[Pd]>[NH2:1][CH2:2][C:3]([NH:5][C@H:6]([C:14]([NH:16][CH2:17][C:18]([N:20]1[CH2:62][CH2:61][CH2:60][C@H:21]1[C:22]([NH:24][C@H:25]([C:35]([NH:37][C@H:38]([C:46]([N:48]1[CH2:59][CH2:58][CH2:57][C@H:49]1[C:50]([O:52][C:53]([CH3:56])([CH3:55])[CH3:54])=[O:51])=[O:47])[C@@H:39]([CH3:45])[O:40][C:41]([CH3:42])([CH3:43])[CH3:44])=[O:36])[CH2:26][CH2:27][C:28](=[O:34])[O:29][C:30]([CH3:31])([CH3:33])[CH3:32])=[O:23])=[O:19])=[O:15])[CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:4]

Participants

4

Reactant 1

HCID 131710229HCID 131710229, compound

Product 1

HCID 131710228HCID 131710228, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

858 mg of Z-Gly-Phe-Gly-Pro-Glu(OtBu)-Thr(tBu)-Pro-OtBu are hydrogenated in 150 ml of methanol in the presence of 200 mg of palladium-carbon catalyst (10% Pd). The product is triturated with ether×hexane (1:1) to form an amorphous powder. In the thin-layer chromatogram on silica gel it shows the following values:

Workup

  1. customThe product is triturated with ether×hexane (1:1)
  2. customto form an amorphous powder

Sources & evidence

ORD record
ord-65e6a1dcedab4c17abcb982ea4c016dc
Source dataset
uspto-grants-1976_05
Patent number
US03956260

Reaction notes

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