反应详情

A 500 ml. reaction flask equipped with stirrer, condenser, and Dean Stark trap was charged with 191 g. (1.03 moles) of o-phenoxyphenol, 50 ml. of toluene and 39.5 g. (0.70 mole) of potassium hydroxide. The mixture was heated to reflux and water azeotroped from the system. Diglyme (100 ml.) was then added followed by 20 g. (0.053 mole) of 3-chloro-3'-(m-phenoxyphenoxy)biphenyl over a 30 minute period. To this mixture 2.5 g. of cuprous chloride and 0.5 g. of copper powder was added and after removing the diglyme be distillation, the reaction mixture was heated at 230°-240° for 18 hours. The mixture was cooled, diluted with 500 ml. of ether and centrifuged to remove copper and potassium salts. The salts were washed with additional ether, and the ether fractions combined and washed with 25% potassium hydroxide solution followed by water washing to neutrality. After drying the ethereal solution over magnesium sulfate, and removing ether in vacuo, the resulting oil was distilled to give 16.9 g of the desired product, bp 255°-260°/0.02 mm.; nD25 1.6480.

1. customreaction flask
2. customequipped with stirrer, condenser
3. additionDean Stark trap was charged with 191 g
4. temperatureThe mixture was heated
5. temperatureto reflux
6. customwater azeotroped from the system
7. additionDiglyme (100 ml.) was then added
8. customafter removing the diglyme
9. distillationdistillation
10. temperaturethe reaction mixture was heated at 230°-240° for 18 hours
11. temperatureThe mixture was cooled
12. additiondiluted with 500 ml
13. customto remove copper and potassium salts
14. washThe salts were washed with additional ether
15. washwashed with 25% potassium hydroxide solution
16. dry with materialAfter drying the ethereal solution over magnesium sulfate
17. customremoving ether in vacuo
18. distillationthe resulting oil was distilled