反应详情

A 500 ml. reaction flask equipped with stirrer, condenser and Dean-Stark trap was charged with 59.8 g. (0.215 mole) of m-(m-phenoxyphenoxy)phenol, 50 ml. of toluene and 7.2 g. (0.129 mole) of potassium hydroxide. Water was azeotroped from the system and 100 ml. of diglyme added followed by dropwise addition of 20 g. (0.053 mole) of 3-chloro-3'-(m-phenoxyphenoxy)biphenyl over a 30 min. period. To this mixture 2.5 g. of cuprous chloride and 0.5 g. of copper powder was added. Diglyme was distilled from the system and the resulting mixture heated at 230°-240°C. for 18 hours. At the end of this time, 250 ml. of ether was added to the cooled mixture and the resulting slurry centrifuged to remove salts. The ethereal solution was washed thoroughly with aqueous base, water and then dried over anhydrous magnesium sulfate. The ether was removed under vacuum, and the resulting oil was distilled to give 24.4 g. of the desired product, bp 340°/ 0.05 mm., nD25 1.6510.

1. customreaction flask
2. customequipped with stirrer, condenser
3. additionDean-Stark trap was charged with 59.8 g
4. customWater was azeotroped from the system and 100 ml
5. additionof diglyme added
6. additionfollowed by dropwise addition of 20 g
7. distillationDiglyme was distilled from the system
8. temperaturethe resulting mixture heated at 230°-240°C. for 18 hours
9. additionof ether was added to the cooled mixture
10. customto remove salts
11. washThe ethereal solution was washed thoroughly with aqueous base, water
12. dry with materialdried over anhydrous magnesium sulfate
13. customThe ether was removed under vacuum
14. distillationthe resulting oil was distilled
15. customto give 24.4 g