2H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo- → HCID 131710238, compound

HRID 1076617Notes

Reaction equation

HRID 1076617 reaction equation
[NH2:1][N:2]1[C:11]([OH:20])([C:12]2[C:17]([F:18])=[CH:16][CH:15]=[CH:14][C:13]=2[F:19])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:21])[CH:9]=2)[N:4]=[CH:3]1.[C:22]1(=[O:36])[N:26]([CH2:27][C:28](Cl)=[O:29])[C:25](=[O:31])[C:24]2=[CH:32][CH:33]=[CH:34][CH:35]=[C:23]12>N1C=CC=CC=1>[F:19][C:13]1[CH:14]=[CH:15][CH:16]=[C:17]([F:18])[C:12]=1[C:11]([C:10]1[CH:9]=[C:8]([Cl:21])[CH:7]=[CH:6][C:5]=1[N:4]([CH:3]=[N:2][NH:1][C:28](=[O:29])[CH2:27][N:26]1[C:22](=[O:36])[C:23]2[C:24](=[CH:32][CH:33]=[CH:34][CH:35]=2)[C:25]1=[O:31])[C:28](=[O:29])[CH2:27][N:26]1[C:25](=[O:31])[C:24]2[C:23](=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:22]1=[O:36])=[O:20]

Participants

4

Reactant 2

HCID 812422H-Isoindole-2-acetyl chloride, 1,3-dihydro-1,3-dioxo-HCID 21537306HCID 21537306, compound

Product 1

HCID 131710238HCID 131710238, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

In the manner given in Example 1, 3-amino-6-chloro-3,4-dihydro-4-hydroxy-4-(2,6-difluorophenyl)quinazoline with pyridine is reacted with α-phthalimidoacetyl chloride to give 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(2,6-difluorobenzoyl)-4-chlorophenyl]-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide.

Sources & evidence

ORD record
ord-9ec11323c2bb4c149f7f2afa83c366f1
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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