Trifluoroacetic acid → HCID 21537259, compound

HRID 1076623Notes

Reaction equation

[F:1][C:2]1[CH:48]=[CH:47][CH:46]=[C:45]([F:49])[C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]([CH:28]=[N:29][NH:30]C(=O)CN1C(=O)C2C(=CC=CC=2)C1=O)[C:14](=O)[CH2:15][N:16]1[C:24](=[O:25])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]1=[O:26])=[O:5].FC(F)(F)C(O)=O>>[F:49][C:45]1[CH:46]=[CH:47][CH:48]=[C:2]([F:1])[C:3]=1[C:4](=[O:5])[C:6]1[CH:11]=[C:10]([Cl:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH:28]=[N:29][N:30]=[C:14]1[CH2:15][N:16]1[C:24](=[O:25])[C:23]2=[CH:22][CH:21]=[CH:20][CH:19]=[C:18]2[C:17]1=[O:26]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131710238HCID 131710238, compound

Product 1

HCID 21537259HCID 21537259, compound

Procedure

In the manner given in Example 7, 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(2,6-difluorobenzoyl)-4-chlorophenyl]-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide is heated to 100°-110° C. with trifluoroacetic acid to give 2',6'-difluoro-5-chloro-2-[3-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-dbd0abbbe8494e138eb5607d2678cc13
Source dataset: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03957761

Reaction notes

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