Trifluoroacetic acid → HCID 21537285, compound

HRID 1076624Notes

Reaction equation

[Cl:1][C:2]1[CH:48]=[CH:47][CH:46]=[CH:45][C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[N:13]([CH:28]=[N:29][NH:30][C:31](=O)[CH2:32][N:33]1[C:41](=[O:42])[C:40]2[C:35](=[CH:36][CH:37]=[CH:38][CH:39]=2)[C:34]1=[O:43])C(=O)CN1C(=O)C2C(=CC=CC=2)C1=O)=[O:5].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:48]=[CH:47][CH:46]=[CH:45][C:3]=1[C:4](=[O:5])[C:6]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:7]=1[N:13]1[CH:28]=[N:29][N:30]=[C:31]1[CH2:32][N:33]1[C:34](=[O:43])[C:35]2=[CH:36][CH:37]=[CH:38][CH:39]=[C:40]2[C:41]1=[O:42]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131710239HCID 131710239, compound

Product 1

HCID 21537285HCID 21537285, compound

Procedure

In the manner given in Example 7, 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(o-chlorobenzoyl)-4-fluorophenyl]-1,3-dioxo-2-isoindolineacetamido]methylene]hydrazide is heated to 100°-110°C with trifluoroacetic acid to give 2'-chloro-5-fluoro-2-[3-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-a345aeba98bd46028102623cb59fab21
Source dataset: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03957761

Reaction notes

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