Trifluoroacetic acid → HCID 21537277, compound

HRID 1076625Notes

Reaction equation

[Cl:1][C:2]1[CH:51]=[CH:50][CH:49]=[CH:48][C:3]=1[C:4]([C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:7]=1[N:16]([CH:31]=[N:32][NH:33][C:34](=O)[CH2:35][N:36]1[C:44](=[O:45])[C:43]2[C:38](=[CH:39][CH:40]=[CH:41][CH:42]=2)[C:37]1=[O:46])C(=O)CN1C(=O)C2C(=CC=CC=2)C1=O)=[O:5].FC(F)(F)C(O)=O>>[Cl:1][C:2]1[CH:51]=[CH:50][CH:49]=[CH:48][C:3]=1[C:4](=[O:5])[C:6]1[CH:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[CH:9]=[CH:8][C:7]=1[N:16]1[CH:31]=[N:32][N:33]=[C:34]1[CH2:35][N:36]1[C:44](=[O:45])[C:43]2=[CH:42][CH:41]=[CH:40][CH:39]=[C:38]2[C:37]1=[O:46]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 131710240HCID 131710240, compound

Product 1

HCID 21537277HCID 21537277, compound

Procedure

In the manner given in Example 7, 1,3-dioxo-2-isoindolineacetic acid, [[N-[2-(o-chlorobenzoyl)-4-(trifluoromethyl)phenyl]-1,3-dioxo-2-isoindolineacetamido]methylene] hydrazide is heated to 100°-110°C. with trifluoroacetic acid to give 2'-chloro-5-trifluoromethyl-2-[3-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone.

Sources & evidence

ORD record: ord-63cfcb4aa2fb4c938b32d2c79d899bf4
Source dataset: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US03957761

Reaction notes

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