Hydrazine hydrate (1:1) → HCID 20361351, compound

HRID 1076633Notes

Reaction equation

HRID 1076633 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9](=O)[C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[N:17]1[C:21]([CH2:22][N:23]2C(=O)C3=CC=CC=C3C2=O)=[N:20][N:19]=[C:18]1[CH2:34][N:35]([CH3:37])[CH3:36].O.NN>C(O)C>[Cl:16][C:14]1[CH:13]=[CH:12][C:11]2[N:17]3[C:18]([CH2:34][N:35]([CH3:36])[CH3:37])=[N:19][N:20]=[C:21]3[CH2:22][N:23]=[C:9]([C:3]3[C:4]([F:8])=[CH:5][CH:6]=[CH:7][C:2]=3[F:1])[C:10]=2[CH:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21537262HCID 21537262, compound

Product 1

HCID 20361351HCID 20361351, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 27, 2',6'-difluoro-5-chloro-2-[3-[(dimethylamino)methyl]-5-(phthalimidomethyl)- 4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-chloro-1[(dimethylamino)-methyl]-6-(2,6-difluorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-36dc9aa5e07f41be9758db4fe9718216
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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