Hydrazine hydrate (1:1) → 8-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

HRID 1076634Notes

Reaction equation

HRID 1076634 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:16]2[C:20]([CH2:21][N:22]3C(=O)C4=CC=CC=C4C3=O)=[N:19][N:18]=[C:17]2[CH2:33][N:34]([CH2:37][CH3:38])[CH2:35][CH3:36])=[C:6]([CH:15]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=O.O.NN>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[N:16]3[C:17]([CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38])=[N:18][N:19]=[C:20]3[CH2:21][N:22]=[C:7]([C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:6]=2[CH:15]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 215372635-chloro-2-[3-[(diethylamino)-methyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone

Product 1

HCID 126123578-chloro-1-[(diethyl amino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 27, 5chloro-2-[3-[(diethylamino)methyl]-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-chloro-1-[(diethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Sources & evidence

ORD record
ord-938f4e02f4b04d0dbea5d292620bc03b
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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