Hydrazine hydrate (1:1) → HCID 21537270, compound

HRID 1076637Notes

Reaction equation

HRID 1076637 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1[N:19]1[C:23]([CH2:24][N:25]2[C:29](=O)[C:28]3=[CH:31]C=CC=[C:27]3[C:26]2=O)=[N:22][N:21]=[C:20]1[CH2:36][N:37]1CCCCC1.O.NN>C(O)C>[F:18][C:15]([F:17])([F:16])[C:13]1[CH:12]=[CH:11][C:10]2[N:19]3[C:23]([CH2:24][N:25]4[CH2:29][CH2:31][CH2:28][CH2:27][CH2:26]4)=[N:22][N:21]=[C:20]3[CH2:36][N:37]=[C:8]([C:3]3[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=3[Cl:1])[C:9]=2[CH:14]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21537261HCID 21537261, compound

Product 1

HCID 21537270HCID 21537270, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 27, 2'-chloro-5-trifluoromethyl-2-[3-(piperidinomethyl)-5-(phthalimidomethyl)-4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-trifluoromethyl-1-(piperidinomethyl)-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-91633c9128f547ed8b9419c9ae7ab197
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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