Hydrazine hydrate (1:1) → HCID 12562517, compound

HRID 1076638Notes

Reaction equation

HRID 1076638 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[C:9]1[CH:14]=[C:13](Cl)[CH:12]=[CH:11][C:10]=1[N:16]1[C:20](CN2C(=O)C3=CC=CC=C3C2=O)=NN=[C:17]1[CH2:33][N:34]1CCN(C)CC1.O.[NH2:43][NH2:44]>C(O)C>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:16]2[CH:20]=[N:43][N:44]=[C:17]2[CH2:33][N:34]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 21537256HCID 21537256, compound

Product 1

HCID 12562517HCID 12562517, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the manner given in Example 27, 2',5-dichloro-2-[3-[(4-methylpiperazino)methyl]-5-(phthalimidomethyl)- 4H-1,2,4-triazol-4-yl]benzophenone is heated in ethanol with hydrazine hydrate to give 8-chloro-1-[4-methylpiperazino)methyl]-6-(o-chlorophenyl)-4H-s-triazolo[4,3-a][1,4]-benzodiazepine.

Sources & evidence

ORD record
ord-db9a7e8ac4134b96bb03138e481f440e
Source dataset
uspto-grants-1976_05
Patent number
US03957761

Reaction notes

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