Hydrochloric Acid → Ethyl 2-propylthiazole-5-carboxylate

HRID 1076667Notes

Reaction equation

HRID 1076667 reaction equation
Cl.[CH2:2]([C:5]1[S:6][C:7]([C:10]([OH:12])=[O:11])=[CH:8][N:9]=1)[CH2:3][CH3:4].[CH2:13](O)[CH3:14]>>[CH2:2]([C:5]1[S:6][C:7]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:9]=1)[CH2:3][CH3:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 65773Tizoprolic Acid

Product 1

HCID 21413783Ethyl 2-propylthiazole-5-carboxylate

Procedure

A current of hydrochloric acid gas was passed with stirring through a solution of 30 g of 2-propyl-thiazole-5-carboxylic acid in 400 ml of absolute ethanol overnight and the ethanol was then evaporated off. The oily residue was taken up in ether containing 10% of potassium carbonate and the mixture was extracted with ether. The ether extracts were washed with water until a pH of 6 was obtained and the resulting yellow oil was purified by distillation to obtain 31.2 g of ethyl 2-propyl-thiazole-5-carboxylate with a boiling point of 139°-140°C at 16 mmHg.

Workup

  1. customthe ethanol was then evaporated off
  2. extractionthe mixture was extracted with ether
  3. washThe ether extracts were washed with water until a pH of 6
  4. customwas obtained
  5. distillationthe resulting yellow oil was purified by distillation

Sources & evidence

ORD record
ord-ba76c9ce73d64c5daa36df293c98e450
Source dataset
uspto-grants-1976_05
Patent number
US03957809

Reaction notes

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