反应详情

A stirred mixture of 24 g. of ethyl picolinate, 18 g. of cyclopropylmethyl ketone and 11 g. of sodium methoxide in 250 ml. of benzene is heated under reflux for 6 hours. The mixture is diluted with 200 ml. of water and the water phase is removed. The aqueous solution is made weakly acidic with dilute hydrochloric acid. A solid precipitates and is collected by filtration. Recrystallization from cyclohexane provided colorless crystals, melting point 77°-78°C.

1. additionA stirred mixture of 24 g
2. temperatureunder reflux for 6 hours
3. additionThe mixture is diluted with 200 ml
4. customof water and the water phase is removed
5. customA solid precipitates
6. filtrationis collected by filtration
7. customRecrystallization from cyclohexane provided colorless crystals, melting point 77°-78°C.