反应详情

A stirred mixture of 4.0 g. of ethyl-3-pyridazinecarboxylate, 4.4 g. of cyclopropylmethyl ketone and 1.6 g. of sodium methoxide in 100 ml. of benzene is heated under reflux for 5 hours. The mixture is diluted with 300 ml. of water and the benzene phase is separated. The aqueous mixture is made weakly acidic with dilute hydrochloric acid and extracted with chloroform. The chloroform solution is dried over magnesium sulfate and concentrated under reduced pressure to yield straw-colored crystals which are recrystallized from acetonitrile to give cream-colored crystals, melting point 85°-87°C.

1. additionA stirred mixture of 4.0 g
2. temperatureunder reflux for 5 hours
3. additionThe mixture is diluted with 300 ml
4. customof water and the benzene phase is separated
5. extractionextracted with chloroform
6. dry with materialThe chloroform solution is dried over magnesium sulfate
7. concentrationconcentrated under reduced pressure
8. customto yield straw-colored crystals which
9. customare recrystallized from acetonitrile
10. customto give cream-colored crystals, melting point 85°-87°C.