反应详情

A stirred mixture of 1.4 g. of methyl-4-pyrimidinecarboxylate, 1.7 g. of cyclopropylmethyl ketone, 1.2 g. of sodium methoxide and 40 ml. of benzene is heated under reflux for 4 hours. The mixture is diluted with 40 ml. of water and the benzene phase is removed. The aqueous mixture is made weakly acidic with dilute hydrochloric acid and extracted with chloroform. The cloroform solution is dried over magnesium sulfate and concentrated under reduced pressure to give light brown crystals, which are recrystallized from hexane to provide straw-colored crystals, melting point 81°-84°C.

1. additionA stirred mixture of 1.4 g
2. temperatureunder reflux for 4 hours
3. additionThe mixture is diluted with 40 ml
4. customof water and the benzene phase is removed
5. extractionextracted with chloroform
6. dry with materialThe cloroform solution is dried over magnesium sulfate
7. concentrationconcentrated under reduced pressure
8. customto give light brown crystals, which
9. customare recrystallized from hexane
10. customto provide straw-colored crystals, melting point 81°-84°C.