反应详情

To a stirred mixture containing 3.8 g. of isonicotinoyl chloride, oxime hydrochloride and 1.4 g. of vinylcyclopropane in 100 ml. of ethanol is added dropwise over a 1 hour period, a solution 4.1 g. of triethylamine in 40 ml. of ethanol. The reaction is stirred for 1 hour and then the solvent is removed under reduced pressure. The residue is extracted with ether and the ether solution is dried over sodium sulfate. The solution is filtered and then the solvent is removed giving a yellow solid. The solid is recrystallized from ethanol giving white crystals, melting point 102°-108°C.

1. additionTo a stirred mixture containing 3.8 g
2. customthe solvent is removed under reduced pressure
3. extractionThe residue is extracted with ether
4. dry with materialthe ether solution is dried over sodium sulfate
5. filtrationThe solution is filtered
6. customthe solvent is removed
7. customgiving a yellow solid
8. customThe solid is recrystallized from ethanol giving white crystals, melting point 102°-108°C.