3-Chloro-N,N-dimethyl-1-propanamine → HCID 12826087, compound

HRID 1076728Notes

Reaction equation

HRID 1076728 reaction equation
[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][Cl:6].[C:8]1([CH:14]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[C:16]3([CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[O:15]2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[ClH:6].[CH3:1][N:2]([CH3:7])[CH2:3][CH2:4][CH2:5][C:14]1([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[C:16]2([CH2:21][CH2:20][O:19][CH2:18][CH2:17]2)[O:15]1

Participants

3

Reactant 2

HCID 669603-Chloro-N,N-dimethyl-1-propanamineHCID 12826085HCID 12826085, compound

Product 1

HCID 12826087HCID 12826087, compound

Procedure

By following the manipulative procedure described above in Example 1c, 3-dimethylaminopropyl chloride is reacted with 1,2',3,3',5',6'-hexahydro-3-phenylspiro(isobenzofuran-1,4'-pyran). The hydrochloride salt of the product is recrystallized from an acetone-ethyl ether mixture to give 3-(3-dimethylaminopropyl)-1,2',3,3',5',6'-hexahydro-3-phenylspiro[isobenzofuran-1,4'-pyran] hydrochloride, m.p. 234.5° - 235.5°C.

Workup

  1. customThe hydrochloride salt of the product is recrystallized from an acetone-ethyl ether mixture

Sources & evidence

ORD record
ord-8a31128ec994482a842503ae49020aa6
Source dataset
uspto-grants-1976_05
Patent number
US03957828

Reaction notes

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