Hydrochloric Acid → 5-Methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate

Participants

Reaction Steps

A solution of 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole (0.369 g.) in ethanol (14 ml.) is treated at room temperature with a solution of dry hydrogen chloride in ethanol (0.37 ml. of 10% w v solution) and the mixture kept at room temperature for 24 hours. The precipitate which forms is collected by filtration, washed with dry ether and dried to give 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate, m.p. 196° - 199°C. with previous softening. Elemental analysis satisfactory for C20H24ClN3O2S.1/2H2O.

Provenance & Evidence