Hydrochloric Acid → 5-Methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate

HRID 1076835노트

반응식

HRID 1076835 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:14][CH:13]=3)=[N:8][C:7]=2[CH:26]=1.[ClH:27]>C(O)C>[OH2:2].[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:16][CH:17]=3)=[N:8][C:7]=2[CH:26]=1.[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:16][CH:17]=3)=[N:8][C:7]=2[CH:26]=1.[ClH:27]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 38054Benzothiazole, 5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)-

생성물 1

HCID 1317102445-Methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole (0.369 g.) in ethanol (14 ml.) is treated at room temperature with a solution of dry hydrogen chloride in ethanol (0.37 ml. of 10% w v solution) and the mixture kept at room temperature for 24 hours. The precipitate which forms is collected by filtration, washed with dry ether and dried to give 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate, m.p. 196° - 199°C. with previous softening. Elemental analysis satisfactory for C20H24ClN3O2S.1/2H2O.

후처리

  1. filtrationThe precipitate which forms is collected by filtration
  2. washwashed with dry ether
  3. customdried

출처 및 근거

ORD 기록
ord-066a98d7945f4c218770afb1554803d5
출처 데이터셋
uspto-grants-1976_05
특허 번호
US03957999

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