HRID1076835

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：COc1ccc2sc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1

HCID38054

Benzothiazole, 5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)-

C20H23N3O2S

PRODUCTS

生成物

结构：COc1ccc2sc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1.COc1ccc2sc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1.Cl.Cl.O

HCID131710244

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A solution of 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole (0.369 g.) in ethanol (14 ml.) is treated at room temperature with a solution of dry hydrogen chloride in ethanol (0.37 ml. of 10% w v solution) and the mixture kept at room temperature for 24 hours. The precipitate which forms is collected by filtration, washed with dry ether and dried to give 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole hydrochloride hemihydrate, m.p. 196° - 199°C. with previous softening. Elemental analysis satisfactory for C20H24ClN3O2S.1/2H2O.

WORKUP

后处理

filtrationThe precipitate which forms is collected by filtration
washwashed with dry ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-066a98d7945f4c218770afb1554803d5
来源数据集: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03957999
来源说明: uspto-grants-1976_05

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:14][CH:13]=3)=[N:8][C:7]=2[CH:26]=1.[ClH:27]>C(O)C>[OH2:2].[ClH:27].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:16][CH:17]=3)=[N:8][C:7]=2[CH:26]=1.[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:16][CH:17]=3)=[N:8][C:7]=2[CH:26]=1.[ClH:27]