HRID1076836

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID311

Citric acid

C6H8O7

结构：COc1ccc2sc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1

HCID38054

Benzothiazole, 5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)-

C20H23N3O2S

PRODUCTS

生成物

结构：COc1ccc2sc(Nc3ccc(OCCN4CCCC4)cc3)nc2c1.O=C(O)CC(O)(CC(=O)O)C(=O)O

HCID86733438

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

2 次

PROCEDURE

实验过程

A hot solution of 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole (0.738 g.) in ethanol (45 ml.) is treated with a hot solution of citric acid (0.384 g.) in ethanol (2.5 ml.). The solution is allowed to cool to room temperature and then kept at 0° - 10°C. overnight. The precipitate which forms is collected by filtration, washed with ethanol and dried to give 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole citrate, m.p. 155° - 156°C. (dec.) with previous softening. Elemental analysis satisfactory for C26H31N3O9S.

WORKUP

后处理

filtrationThe precipitate which forms is collected by filtration
washwashed with ethanol
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-65b1f206c2d0486ebe42e5141e51de1d
来源数据集: uspto-grants-1976_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US03957999
来源说明: uspto-grants-1976_05

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:14][CH:13]=3)=[N:8][C:7]=2[CH:26]=1.[C:27]([OH:39])(=[O:38])[CH2:28][C:29]([CH2:34][C:35]([OH:37])=[O:36])([C:31]([OH:33])=[O:32])[OH:30]>C(O)C>[C:27]([OH:39])(=[O:38])[CH2:28][C:29]([CH2:34][C:35]([OH:37])=[O:36])([C:31]([OH:33])=[O:32])[OH:30].[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([NH:11][C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:16][CH:17]=3)=[N:8][C:7]=2[CH:26]=1