HuagongsheHuagongshe Chemistry Print Report · For research reference only
Citric Acid → 5-Methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole citrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Citric Acid | HCID 311 | — |
| Reactant | Benzothiazole, 5-methoxy-2-(beta-(1-pyrrolidinyl)-p-phenetidino)- | HCID 38054 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole citrate | HCID 86733438 | — |
Reaction Steps
A hot solution of 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole (0.738 g.) in ethanol (45 ml.) is treated with a hot solution of citric acid (0.384 g.) in ethanol (2.5 ml.). The solution is allowed to cool to room temperature and then kept at 0° - 10°C. overnight. The precipitate which forms is collected by filtration, washed with ethanol and dried to give 5-methoxy-2-[4-(2-pyrrolidin-1-ylethoxy)anilino]benzothiazole citrate, m.p. 155° - 156°C. (dec.) with previous softening. Elemental analysis satisfactory for C26H31N3O9S.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03957999 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-65b1f206c2d0486ebe42e5141e51de1d |
| Source note | uspto-grants-1976_05 |