Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl benzylidenecyanoacetate → 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl benzylidenecyanoacetate | HCID 74845 | — |
| 반응물 | Sodium ethoxide | HCID 2723922 | — |
| 반응물 | Amidinoacetic acid isopropyl ester | HCID 12391080 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2,6-Diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester | HCID 70631841 | 54% |
반응 단계
Upon heating a solution of 10.1 g benzylidenecyanoacetic acid ethyl ester, 7.2 g amidinoacetic acid isopropyl ester and 0.6 g sodium ethylate in 150 ml ethanol for 4 hours, 2,6-diamino-4-phenyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl ester 5-isopropyl ester of m.p. 170° is obtained. Yield: 54% of theory.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03957998 |
| 출처 데이터셋 | uspto-grants-1976_05 |
| ORD ID | ord-e588e6cf99be4fe0960e71463b891ee0 |
| 출처 메모 | uspto-grants-1976_05 |