HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbamimidoyl-acetic acid ethyl ester → 2,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbamimidoyl-acetic acid ethyl ester | HCID 4599837 | — |
| Reactant | Ethyl 3-formylbenzoate | HCID 11084437 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 70631688 | 32% |
Reaction Steps
Upon boiling a solution of 8.9 g 3-carbethoxybenzaldehyde and 13.0 g amidinoacetic acid ethyl ester in 100 ml ethanol for 2 hours, 2,6-diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 191°C (ethanol) is obtained. Yield: 32% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03957998 |
| Source dataset | uspto-grants-1976_05 |
| ORD ID | ord-9d648254597c4ab3a7caa0055edcb69e |
| Source note | uspto-grants-1976_05 |