Methyl Isocyanate → 4-(5-Chloro-3-methylcarbamoylspiro[indan-1,3'-pyrrolidin]-1'-yl)-p-fluorobutyrophenone

HRID 1076888Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1076888
[Cl:1][C:2]1[CH:3]=[C:4]2[C:24](=[CH:25][CH:26]=1)[C:7]1([CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[O:16])[CH2:8]1)[CH2:6][CH:5]2O.[CH3:28][N:29]=[C:30]=[O:31].C(O)(=O)/C=C/C([O-])=O>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:24](=[CH:25][CH:26]=1)[C:7]1([CH2:11][CH2:10][N:9]([CH2:12][CH2:13][CH2:14][C:15]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[O:16])[CH2:8]1)[CH2:6][CH:5]2[C:30](=[O:31])[NH:29][CH3:28]

Komponenten

5

Edukt 3

HCID 12228Methyl IsocyanateHCID 6183479Fumarate(1-)HCID 215386414-(5-Chloro-3-hydroxyspiro[indan-1,3'-pyrrolidin]-1'-yl)-p-fluorobutyrophenone

Produkt 1

HCID 215386924-(5-Chloro-3-methylcarbamoylspiro[indan-1,3'-pyrrolidin]-1'-yl)-p-fluorobutyrophenone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

4-(5-Chloro-3-hydroxyspiro[indan-1,3'-pyrrolidin]-1'-yl)-p-fluorobutyrophenone is reacted with methyl isocyanate in chloroform in a manner analogous to that described in Example 19. Reaction time 24 hours at the boil. The hydrogen fumarate of the title compound has a M.P. of 151°-153° (from ethanol/ether).

Aufarbeitung

  1. customReaction time 24 hours at the boil

Quellen und Nachweise

ORD-Eintrag
ord-57fbfc9afb22456286dfbd33ea3257ea
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03958003

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