Hydrochloric Acid → HCID 21538576, compound

HRID 1076915Notes

Reaction equation

HRID 1076915 reaction equation
C1(=O)[N:5]([CH2:6][CH2:7][CH2:8][C:9]([C:11]2[CH:24]=[CH:23][C:22]3[O:21][C:20]4[C:15](=[CH:16][C:17]([C:25](=[O:40])[CH2:26][CH2:27][CH2:28][N:29]5C(=O)C6=CC=CC=C6C5=O)=[CH:18][CH:19]=4)[CH2:14][C:13]=3[CH:12]=2)=[O:10])C(=O)C2=CC=CC=C12.C1(=O)N(CCCC([Cl:57])=O)C(=O)C2=CC=CC=C12.C1C2CC3C(=CC=CC=3)OC=2C=CC=1.[ClH:78]>C(O)(=O)C>[ClH:57].[ClH:78].[NH2:29][CH2:28][CH2:27][CH2:26][C:25]([C:17]1[CH:18]=[CH:19][C:20]2[O:21][C:22]3[C:13](=[CH:12][C:11]([C:9](=[O:10])[CH2:8][CH2:7][CH2:6][NH2:5])=[CH:24][CH:23]=3)[CH2:14][C:15]=2[CH:16]=1)=[O:40]

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 7107XantheneHCID 5948864-(1,3-Dioxoisoindolin-2-yl)butanoyl chlorideHCID 21538574HCID 21538574, compound

Product 1

HCID 21538576HCID 21538576, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2,7-Bis(4-phthalimidobutyryl)xanthene, prepared from 4-phthalimidobutyryl chloride and xanthene by the method of S. S. Cheng et al., J. Med. Chem. 9, 945 (1966), is treated with 700 ml. of hot glacial acetic acid after which 200 ml. of concentrated hydrochloric acid is added gradually with stirring. The mixture is heated to reflux for 24 hours with a constant stream of HCl gas passing through the mixture The reaction mixture is stirred and refluxed for an additional 24 hours, cooled, and the product worked up in the usual manner.

Workup

  1. addition9, 945 (1966), is treated with 700 ml
  2. temperatureThe mixture is heated
  3. stirringis stirred
  4. temperaturerefluxed for an additional 24 hours
  5. temperaturecooled

Sources & evidence

ORD record
ord-48f747910c064377ac980362554069e3
Source dataset
uspto-grants-1976_05
Patent number
US03957989

Reaction notes

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