反应详情

14.8 g of 3-(amino-benzoyl)thiophene, 23.8 g of solid potassium hydroxide and 19.6 g of hydrazine hydrate are heated to the boil at reflux in 180 cc of diethylene glycol for 3 hours. After diluting the reaction mixture with ice water, extraction is effected with ether. The ether phase is washed thrice with water, is dried with sodium sulphate and concentrated. 3-(2-amino-benzyl)thiophene is obtained in the form of a light yellow oil having a B.P. of 121°-123° 10.05 mm Hg.

1. additionAfter diluting the reaction mixture
2. extractionwith ice water, extraction
3. washThe ether phase is washed thrice with water
4. dry with materialis dried with sodium sulphate
5. concentrationconcentrated