Maleic Acid → HCID 68138529, compound

HRID 1076979Notes

Reaction equation

HRID 1076979 reaction equation
[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][CH:4]([CH2:18][O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:3]1.[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=[O:30]>C(OCC)C>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]\[C:29]([OH:31])=[O:30].[CH3:1][N:2]1[C@H:16]2[C@@H:6]([C:7]3[CH:8]=[CH:9][CH:10]=[C:11]4[C:17]=3[C:14]([CH2:15]2)=[CH:13][NH:12]4)[CH2:5][CH:4]([CH2:18][O:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[CH2:3]1

Participants

4

Reactant 2

HCID 444266Maleic AcidHCID 68138530HCID 68138530, compound

Product 1

HCID 68138529HCID 68138529, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 3.3 g. of 6-methyl-8-phenoxymethylergoline in 50 ml. of diethyl ether was stirred while a solution of 0.58 g. of maleic acid in 10 ml. of diethyl ether was added in one portion. After stirring for about 1 hour, the crystalline 6-methyl-8-phenoxymethylergoline maleate salt was collected by filtration.

Workup

  1. filtrationthe crystalline 6-methyl-8-phenoxymethylergoline maleate salt was collected by filtration

Sources & evidence

ORD record
ord-f5609e9a2f14459285126760d73ede60
Source dataset
uspto-grants-1976_05
Patent number
US03959288

Reaction notes

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