Hydrochloric Acid → HCID 12403038, compound

HRID 1076986Notes

Reaction equation

HRID 1076986 reaction equation
[Cl:1][C:2]1[C:3]2[NH:24][C:23]([C:25]([O:27]C)=[O:26])=[CH:22][C:21](=[O:29])[C:4]=2[C:5]([C:17]([F:20])([F:19])[F:18])=[C:6]2[C:11]=1[NH:10][C:9]([C:12]([O:14]C)=[O:13])=[CH:8][C:7]2=[O:16].[OH-].[Na+].Cl>O>[Cl:1][C:2]1[C:11]2[NH:10][C:9]([C:12]([OH:14])=[O:13])=[CH:8][C:7](=[O:16])[C:6]=2[C:5]([C:17]([F:19])([F:18])[F:20])=[C:4]2[C:3]=1[NH:24][C:23]([C:25]([OH:27])=[O:26])=[CH:22][C:21]2=[O:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12403037HCID 12403037, compound

Product 1

HCID 12403038HCID 12403038, compoundYield 47.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1.65 grams (0.0058 mole) of dimethyl 10-chloro-1,4,6,9-tetrahydro-4,6-dioxo-5-(trifluoromethyl)pyrido[3,2-g]quinoline-2,8-dicarboxylate and 20 ml. of water is stirred and to the mixture is added a 5% sodium hydroxide solution until solution occurs (3ml.). The solution is stirred for 15 minutes and then acidified by the addition of a dilute HCl solution. The resulting tan precipitate is removed by filtration and washed with water. There is obtained 1.11 gram of material melting above 300°.

Workup

  1. customThe resulting tan precipitate is removed by filtration
  2. washwashed with water

Sources & evidence

ORD record
ord-06dc7e42eb1f41be9ef724c9ef26b4fc
Source dataset
uspto-grants-1976_05
Patent number
US03959289

Reaction notes

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