反应详情

40 g of ammonia gas is introduced in the course of about 4 hours at 13°-15°C into a mixture consisting of 126 g of acetone, 22.5 g of methanol and 4.7 g of ammonium chloride. The reaction mixture is subsequently stirred for a further 30 minutes at the same temperature. An addition is then made to the reaction mixture of 220 g of diacetone alcohol and 110 g of acetone; the whole is heated within 1 hour to 55°C and held at this temperature for 12 hours. Processing by fractional distillation yields 125 g of 2,2,6,6-tetramethyl-4-oxopiperidine.

1. additionAn addition
2. temperaturethe whole is heated within 1 hour to 55°C
3. waitheld at this temperature for 12 hours
4. distillationProcessing by fractional distillation