1,4-Dibromobutane → 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione

HRID 1076995Notes

Reaction equation

HRID 1076995 reaction equation
Cl.[O:2]=[C:3]1[C:12]2[C:7]3[C:8](=[CH:13][CH:14]=[CH:15][C:6]=3[C:5](=[O:16])[N:4]1[CH2:17]CCCN1CCC(N(C3C=CC=CC=3)C(=O)CC)CC1)[CH:9]=[CH:10][CH:11]=2.[Br:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]CBr.BrCCCCBr>>[Br:38][CH2:39][CH2:40][CH2:41][CH2:42][CH2:43][CH2:17][N:4]1[C:5](=[O:16])[C:6]2[CH:15]=[CH:14][CH:13]=[C:8]3[C:7]=2[C:12](=[CH:11][CH:10]=[CH:9]3)[C:3]1=[O:2]

Participants

4

Reactant 3

HCID 80561,4-DibromobutaneHCID 123681,6-DibromohexaneHCID 131710247N-[1-[4-(1,3-dihydro-1,3-dioxo-2H-benz[de]isoquinolin-2-yl)butyl]-4-piperidinyl]-N-phenylpropanamide, hydrochloride

Product 1

HCID 203645072-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione

Procedure

Following the procedure of part (a) of example 31 but substituting 1,6-dibromohexane for the 1,4-dibromobutane, one obtains 2-(6-bromohexyl)-1H-benz[de]isoquinoline-1,3(2H)-dione; m.p. 95°-96°.

Sources & evidence

ORD record
ord-9295c8121a634e6394e96ddfe9169ed1
Source dataset
uspto-grants-1976_05
Patent number
US03959286

Reaction notes

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