Sodium Hydroxide → HCID 54502363, compound

Participants

Reaction Steps

To 69.5 parts 2-methyl-2-thiopseudourea sulfate and 110 parts methyl chlorothioformate in 500 ml. of water is added dropwise at 0°-5°C. 120 parts 50% sodium hydroxide. The reaction mixture is stirred at 0°-5°C. for 1 hour and then at room temperature for 2 hours. The solution is extracted with methylene chloride. The methylene chloride extract is then dried and the solvent evaporated on a rotary evaporator to give 47 parts of methyl N-(1-amino-1-methylthiomethylene)thiocarbamate melting at 75°-76°C.

Provenance & Evidence