2-Methyl-1,3-cyclopentanedione → 2-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione

HRID 1077136Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1077136
[Na].[OH-].[K+].Br[CH2:5][CH2:6][C:7](=[O:19])[CH2:8][CH2:9][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[CH:12]=1.[CH3:20][CH:21]1[C:25](=[O:26])[CH2:24][CH2:23][C:22]1=[O:27]>>[CH3:18][O:17][C:13]1[CH:12]=[C:11]([CH2:10][CH2:9][CH2:8][C:7](=[O:19])[CH2:6][CH2:5][C:21]2([CH3:20])[C:25](=[O:26])[CH2:24][CH2:23][C:22]2=[O:27])[CH:16]=[CH:15][CH:14]=1

Komponenten

5

Edukt 4

HCID 130052-Methyl-1,3-cyclopentanedioneHCID 14797Potassium HydroxideHCID 5360545SodiumHCID 21485513HCID 21485513, Verbindung

Produkt 1

HCID 203500022-(6-m-Methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione

Versuchsvorschrift

Add sodium (0.05 g) to a 0.12% methanolic potassium hydroxide solution (15 cc). To this solution add 1-bromo-6-(m-methoxyphenyl)hexan-3-one (0.9 g) in methaol (5 cc) and 2-methylcyclopentane-1,3-dione (0.4 g), and reflux the mixture for 6 hours. After working up as in the preparation of the title compound in a previous example, obtain the crude Michael adduct 2-(6-m-methoxyphenyl-3-oxohexyl)-2-methylcyclopentane-1,3-dione as a yellow gum.

Aufarbeitung

  1. temperaturereflux the mixture for 6 hours

Quellen und Nachweise

ORD-Eintrag
ord-c30c62c5a72a467f8c4f2e0bee97c2cc
Quelldatensatz
uspto-grants-1976_05
Patentnummer
US03959322

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