反应详情

Hydrogenate 13β-ethyl-3-hydroxygona-1,3,5(10),8,14-pentaen-17-one (0.5 g.) in benzene (25 cc.) at atmospheric pressure using a 10% palladized charcoal catalyst (0.025 g.). After the absorption of 1.1 molar equivalents of hydrogen, hydrogenation becomes very slow; remove the catalyst by filtration and evaporate the filtrate to obtain the title product which crystallizes from methanol in colorless plates (0.35 g.), m.p. 235°-9°; ultra-violet absorption peak at 280.5 mμ (ε15,500).

1. customAfter the absorption of 1.1 molar equivalents of hydrogen, hydrogenation
2. customremove the catalyst
3. filtrationby filtration
4. customevaporate the filtrate