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HRID1077219

反应详情

EQUATION

反应方程式

HRID 1077219 的结构方程式

REACTANTS

反应物

3
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：O
HCID962

Water

H2O

结构：C#C[C@]1(O)CC[C@H]2[C@@H]3CC(C)C4=C(CC=C(OC)C4)[C@H]3CC[C@@]21CC
HCID86733488

未命名化合物

PRODUCTS

生成物

1
结构：C#C[C@]1(O)CC[C@H]2[C@@H]3C[C@H](C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@@]21CC
HCID86733489

未命名化合物

收率 17.9%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Stir dl-13-ethyl-3-methoxy-17α-ethynyl-17-hydroxy-6-methylgona-2,5(10)-diene (3.5 g) in methanol (90 cc) containing hydrochloric acid (60 cc) and water (4.0 ml) under nitrogen for one hour. Isolate the crude product, chromatograph on Florex (150 g) and recrystallize from ethyl acetate-hexane to obtain the title compound (0.60 g), m.p. 148°-151°, λ max. CHCl3 2.55 μ, 3.05 μ, 6.01 μ; λ max. EtOH 240 mμ (ε15,000).

WORKUP

后处理

  1. customIsolate the crude product, chromatograph on Florex (150 g)
  2. customrecrystallize from ethyl acetate-hexane