n-(3-chloro-4-nitrophenyl)acetamide → 2-Ethylthio-4-Acetylaminonitrobenzene

HRID 1077376Notes

Reaction equation

HRID 1077376 reaction equation
[S-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[CH:11]=[C:10]([NH:12][C:13](=[O:15])[CH3:14])[CH:9]=[CH:8][C:7]=1[N+:16]([O-:18])=[O:17]>C(COC)OC>[CH2:2]([S:1][C:6]1[CH:11]=[C:10]([NH:12][C:13](=[O:15])[CH3:14])[CH:9]=[CH:8][C:7]=1[N+:16]([O-:18])=[O:17])[CH3:3]

Participants

4

Reactant 2

HCID 236820n-(3-chloro-4-nitrophenyl)acetamideHCID 4459711Sodium ethanethiolate

Product 1

HCID 194311352-Ethylthio-4-Acetylaminonitrobenzene

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To a suspension of 25.2 g (0.3 mol) of sodium thioethoxide in 220 ml of dimethoxyethane at room temperature are added, portionwise over 30 minutes with stirring, 46.2 g (0.216 mol) of 2-chloro-4-acetylaminonitrobenzene.

Workup

  1. additionare added, portionwise over 30 minutes

Sources & evidence

ORD record
ord-6945b1e15ae84d1fbc06cbdf82481a3e
Source dataset
uspto-grants-1996_08
Patent number
US05542952

Reaction notes

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