2-Mercaptoethanol → 2-(beta-Hydroxyethylthio)-4-Acetylaminonitrobenzene

HRID 1077378Notes

Reaction equation

HRID 1077378 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[SH:15][CH2:16][CH2:17][OH:18]>>[OH:18][CH2:17][CH2:16][S:15][C:2]1[CH:7]=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13]

Participants

3

Reactant 2

HCID 15672-MercaptoethanolHCID 236820n-(3-chloro-4-nitrophenyl)acetamide

Product 1

HCID 194311222-(beta-Hydroxyethylthio)-4-Acetylaminonitrobenzene

Procedure

Starting with 42.9 g (0.2 mol) of 2-chloro-4-acetylaminonitrobenzene and 23.4 g (0.3 mol) of 2-mercaptoethanol, pale yellow crystals (46.6 g) of the expected compound are obtained, the melting point of which is 174° C. (recrystallized from 96° ethanol) and the elemental analysis of which, calculated for C10H12N2O4S.1/2CH3CH2OH, is:

Sources & evidence

ORD record
ord-5b90eb4aadb64a57a5463eaf147895a4
Source dataset
uspto-grants-1996_08
Patent number
US05542952

Reaction notes

Loading…