Glutaric anhydride → HCID 23367636, compound

HRID 1077402Notes

Reaction equation

HRID 1077402 reaction equation
C(O[C:9]([N:11]1[CH2:16][CH2:15][N:14]([C:17]([N:19]2[C:25]3[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=3[CH:23]=[CH:22][C:21]3[CH:30]=[CH:31][CH:32]=[CH:33][C:20]2=3)=[O:18])[CH2:13][CH2:12]1)=[O:10])C1C=CC=CC=1.Br.N1(C(N2C3C=CC=CC=3C=CC3C=CC=CC2=3)=O)CCNCC1.C1(=O)[O:64][C:62](=[O:63])[CH2:61][CH2:60][CH2:59]1>>[C:62]([CH2:61][CH2:60][CH2:59][C:9]([N:11]1[CH2:12][CH2:13][N:14]([C:17]([N:19]2[C:20]3[CH:33]=[CH:32][CH:31]=[CH:30][C:21]=3[CH:22]=[CH:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][C:25]2=3)=[O:18])[CH2:15][CH2:16]1)=[O:10])([OH:64])=[O:63]

Participants

4

Reactant 3

HCID 7940Glutaric anhydrideHCID 23367631HCID 23367631, compoundHCID 23367634HCID 23367634, compound

Product 1

HCID 23367636HCID 23367636, compound

Procedure

These materials were prepared using the procedures outlined in Steps 2 and 3 of Preparatory Example 2, except starting with 5-[4-(benzyloxycarbonyl)piperazinocarbonyl]-5H-dibenzo[b,f]azepine in place of the N-[3-(benzyloxycarbonylamino)propyl]carbamazepine in step 2, and thus the product 5-(Piperazinocarbonyl)-5H-dibenzo-[b,f]azepine Hydrobromide in place of the product of step 2, and glutaric anhydride in place of succinic anhydride in the procedures of step 3. The residue (2B) was crystallized from ethyl acetate (10 mL) and petroleum ether (2 mL), placed in a freezer, and filtered to give the acid.

Workup

  1. customThese materials were prepared
  2. customThe residue (2B) was crystallized from ethyl acetate (10 mL) and petroleum ether (2 mL)
  3. filtrationfiltered
  4. customto give the acid

Sources & evidence

ORD record
ord-ac796625b5714709aad8fdb77364293c
Source dataset
uspto-grants-1996_08
Patent number
US05543311

Reaction notes

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