HCID 54029226, compound → HCID 19431958, compound

HRID 1077557Notes

Reaction equation

HRID 1077557 reaction equation
CN(C)[CH:3]=[CH:4][C:5]([C:7]1[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[CH:10]=[N:9][CH:8]=1)=O.[N+]([O-])(O)=O.[F:22][C:23]([F:38])([O:27][C:28]1[CH:29]=[C:30]([NH:34][C:35]([NH2:37])=[NH:36])[CH:31]=[CH:32][CH:33]=1)[CH:24]([F:26])[F:25]>>[F:22][C:23]([F:38])([O:27][C:28]1[CH:29]=[C:30]([NH:34][C:35]2[N:37]=[C:5]([C:7]3[C:16]4[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=4)[CH:10]=[N:9][CH:8]=3)[CH:4]=[CH:3][N:36]=2)[CH:31]=[CH:32][CH:33]=1)[CH:24]([F:25])[F:26]

Participants

3

Reactant 2

HCID 54029226HCID 54029226, compoundHCID 1785125183-(1,1,2,2-Tetrafluoroethoxy)phenylguanidine nitrate

Product 1

HCID 19431958HCID 19431958, compound

Procedure

In accordance with the general procedure described in Example 1, reaction of 226.2 mg (1.0 mmol) of 3-dimethylamino-(4-isoquinolyl)-2-propen-1-one and 185 g (0.60 mmol) of 3-(1,1,2,2-tetrafluoroethoxy)phenylguanidine nitrate gives N-[3-(1,1,2,2-tetrafluoroethoxy)phenyl]-4-(4-isoquinolyl)-2-pyrimidine-amine; FAB-MS:415 (M+ +1), m.p. 158°-160° C.

Sources & evidence

ORD record
ord-2657ec1bace84052878c9e8b9e7a2f1b
Source dataset
uspto-grants-1996_08
Patent number
US05543520

Reaction notes

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