Trifluoroacetic acid → 17beta-N,N-Diethylcarbamoyl-6-azaandrost-1,4-dien-3-one

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Reaction Steps

A sample of 17β-N,N-diethylcarbamoyl-6-t-butylcarboxy-6-azaandrost-1,4-dien-3-one (188 mg, 0.400 mmol), prepared in part B above, is treated with trifluoroacetic acid as described in Example 4 above to give, after trituration with diethyl ether/hexanes 17β-N,N-diethylcarbamoyl-6-azaandrost-1,4-dien-3-one as a pale yellow solid; yield: 98 mg (66%); m.p.>250° C. Anal. Calcd. for C23H34N2O2 ·1/2H2O; C, 72.78; H, 9.29; N, 7.38. Found: C, 72.89; H, 9.20; N, 7.43.

Provenance & Evidence